The protein product from this gene referred to as CD45 is a member of the protein tyrosine phosphatase family. PTPs are signaling proteins that regulate various cellular processes like cell differentiation, cell growth as well as mitotic cycle, and oncogenic transformation.
CD45 has an extracellular domain and a transmembrane segment that is a single one as well as two tandem intracytoplasmic catalytic regions and therefore is part of the receptor class PTP family. You can know more about CD45/Ptprc Antibody online.
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CD45 can be found in a variety of isoforms of all differentiated hematopoietic cell types (except plasma cells and erythrocytes). CD45 has been proven to be a key regulator of B-cell and T-cell Antigen receptor-mediated signaling. CD45 also inhibits JAK kinases and acts as an antagonist of the signaling of cytokine receptors.
CD45 is a member of the protein family consisting of several members that are all the result of one complex gene. CD45 is an all-leukocyte protein that has the activity of tyrosine phosphatase that is involved in the regulation of the signal transmission in the hematopoiesis process.
CD45 does not associate with lipid rafts that are present on human and murine hematopoietic non-transformed cells, however, CD45 location within lipid rafts can be altered in the course of their transformation into acute myeloid leukemia.
CD45 is colocalized with lipid rafts that are present on AML cells, contributing to the increased GM-CSF signal strength that is involved in the proliferative leukemic cell proliferation.